Biothera Pharmaceuticals, Inc. is advancing Imprime PGG, a unique cancer immunotherapy, through Phase 2 clinical trials in multiple cancer indications in combination with checkpoint inhibitor therapy. While cancers can actively avoid detection by the immune system, Imprime PGG works as an immunological “ignition switch” to trigger a cascade of responses throughout the innate immune system that culminate in T cell activation. Imprime PGG synergizes with immune checkpoint inhibitors that unleash tumor killing by activated T cells. Studies in more than 400 subjects have demonstrated a favorable safety profile and signals of activity in multiple combinations and tumor types. Patient recruitment is underway for studies in melanoma, triple negative breast cancer and non-small cell lung cancer. Significant milestones, including response, safety and biomarker data, are expected through 2017-18.
About Biothera Pharmaceuticals
For Healthcare Professionals
Brief videos about how Imprime PGG enhances checkpoint inhibitor therapy and the patient selection biomarker for Imprime are designed to provide medical professionals with additional information about Biothera’s clinical development program.
Biothera Pharmaceuticals was recently featured in BioWorld Today, which reported on the Company’s unique PAMP technology, clinical development plans with checkpoint inhibitors and path to FDA approval for Imprime PGG. Learn More
Biothera Pharmaceuticals and its research collaborators are currently seeking patients for clinical studies evaluating Imprime PGG and pembrolizumab (KEYTRUDA®) in the following indications:
- Advanced melanoma
- Metastatic triple negative breast cancer
- Non small cell lung cancer
In addition, a biomarker that may identify patients with the best probability of responding to the developmental therapy is being utilized in the melanoma and triple negative breast cancer study. Learn More
Biothera Pharmaceuticals has partnered with leading pharmaceutical companies and research organizations to advance Imprime PGG and cancer immunotherapy. The Company entered into clinical research agreements with Merck to evaluate Imprime PGG and pembrolizumab (KEYTRUDA®) in multiple indications. Learn More